December 2, 1997European Heart Journal
The GUSTO trial and the open artery theory
Why the study?
Does early and sustained coronary perfusion reduce mortality and morbidity in patients with acute myocardial infarction?
Population
Patients with acute myocardial infarction
Design
Review
Authors
Discussion
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Member takes
Implication
Supports reperfusion in AMI; leaves open optimal strategies for prospective trials.
Structured PICO
Does early and sustained coronary perfusion reduce mortality and morbidity in patients with acute myocardial infarction?
P
Population
Patients with acute myocardial infarction
I
Intervention
Early and sustained coronary perfusion (reperfusion therapy)
O
Outcome
Mortality and morbidityhard clinical
The GUSTO trials support the open artery theory, demonstrating that early and sustained reperfusion reduces mortality and morbidity in acute myocardial infarction.
Cite This Study
Robert M. Califf (1997) studied this question.