Key result
The Quartet lead and Allure Quadra system allow 14 pacing configurations, providing benefits such as reduced phrenic nerve stimulation and improved battery longevity compared to bipolar systems.
Why the study?
Does the Allure Quadra quadripolar pacemaker system improve clinical outcomes and reduce costs compared to traditional bipolar systems in patients with congestive heart failure?
Does the Allure Quadra quadripolar pacemaker system improve clinical outcomes and reduce costs compared to traditional bipolar systems in patients with congestive heart failure?
The Allure Quadra quadripolar pacemaker system offers multiple pacing configurations that may improve clinical and economic outcomes in heart failure patients compared to traditional bipolar CRT.
May support better CRT programming options in HF; leaves open outcome and cost benefits versus bipolar systems in prospective trials.
Congestive heart failure is a major public health epidemic and economic burden in the USA and worldwide. Cardiac resynchronization therapy is an effective therapy for treating congestive heart failure in conjunction with pharmacologic therapy. The average congestive heart failure admission costs approximately US$ 8 billion annually. Current cardiac resynchronization therapy pacemaker systems from various manufacturers deliver therapy-utilizing bipolar leads including the left ventricle, with electrode spacing ranging from 8 to 22 mm. The Quartet LV™ lead model 1458Q (St. Jude Medical Sylmar, CA) is a quadripolar lead with a 4.0 Fr. tip electrode and three 4.7 Fr. ring electrodes located 20, 30 and 47 mm from the tip. The Quartet lead and Allure Quadra TM allows 14 pacing configurations, providing benefits, including reductions in phrenic nerve stimulation, reduced pacing thresholds, improved battery longevity and potential reductions, in non-responders to cardiac resynchronization therapy. In addition, there is cost benefit data from utilizing quadripolar technology compared with traditional bipolar cardiac resynchronization therapy.
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Corbisiero et al. (2014) conducted a review in Congestive heart failure. Allure Quadra quadripolar pacemaker system vs. Traditional bipolar cardiac resynchronization therapy was evaluated. The Quartet lead and Allure Quadra system allow 14 pacing configurations, providing benefits such as reduced phrenic nerve stimulation and improved battery longevity compared to bipolar systems.
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