What does this research mean for the field?

Basic fibroblast growth factor (bFGF) upregulates insulin-like growth factor-I receptor (IGF-IR) gene transcription via a specific promoter region, whereas IGF-I downregulates its transcription without altering mRNA stability. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1997Journal of Biological ChemistryOpen Access

Differential Regulation of Insulin-like Growth Factor-I (IGF-I) Receptor Gene Expression by IGF-I and Basic Fibroblastic Growth Factor

View Full Paper

Ask AI

Bookmark

Authors

CHCatalina Hernández‐SánchezInstituto de Salud Carlos III HWHaim WernerTel Aviv University CRCharles T. RobertsOregon National Primate Research Center

Discussion

Member takes

Implication

bFGF effects on IGF-IR promoter leave open questions on in vivo relevance; hypothesis-generating for growth factor crosstalk.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Hernández‐Sánchez et al. (1997) studied this question.

synapsesocial.com/papers/6a1c0bd04ebd09f3dfa95fb9 https://doi.org/10.1074/jbc.272.8.4663

View Full Paper

Ask AI

Bookmark

Differential Regulation of Insulin-like Growth Factor-I (IGF-I) Receptor Gene Expression by IGF-I and Basic Fibroblastic Growth Factor

Discussion

Member takes

Implication

Key Points

Cite This Study

Differential Regulation of Insulin-like Growth Factor-I (IGF-I) Receptor Gene Expression by IGF-I and Basic Fibroblastic Growth Factor

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider