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December 1, 1969The Journal of General PhysiologyOpen Access

Current Separations in Myxicola Giant Axons

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Authors

LGLawrence GoldmanStevens Institute of TechnologyLBL. BinstockNational Institute of Neurological Disorders and Stroke

Discussion

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Implication

Experimental study reveals external sodium regulates transient currents but not resting potential in Myxicola giant axons, highlighting non-classical resting membrane mechanisms.

Key Points

  • Determine the impact of reducing external sodium concentration on the resting potential, action potential, membrane current, and transient current reversal potential in Myxicola giant axons.
  • Substituted external sodium chloride with Tris chloride, after preliminary tests showed choline and tetramethylammonium chloride produced confounding membrane effects.
  • Measured resting potentials, action potentials, delayed currents, and transient current reversal potentials across altered external sodium concentrations.
  • Transient current was carried predominantly by sodium and its reversal potential closely followed the Nernst equilibrium potential, while delayed current remained independent of external sodium.
  • Peak action potential decreased with reductions in external sodium as predicted for a sodium-dependent action potential with substantial concurrent potassium permeability.
  • Resting membrane potential was completely independent of external sodium concentration, challenging standard Goldman-Hodgkin-Katz formulations based exclusively on sodium and potassium distributions.

Cite This Study

Goldman et al. (1969) studied this question.

synapsesocial.com/papers/6a1c0cc44ebd09f3dfa96109https://doi.org/10.1085/jgp.54.6.741
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of sodium ions on the electrical activity of the giant axon of the squid1949 · 3,554 citations
  2. 2Electronic Measurement of the Intracellular Concentration and Net Flux of Sodium in the Squid Axon1961 · 27 citations
  3. 3Current-Voltage Relations in the Lobster Giant Axon Membrane Under Voltage Clamp Conditions1962 · 165 citations
  4. 4The effects of some ions on the membrane potential of the giant axon of Myxicola1968 · 19 citations
  5. 5Giant Axon of Myxicola : Some Membrane Properties as Observed under Voltage Clamp1967 · 24 citations