Key result
Radiotherapy after anthracycline chemotherapy in lymphoma patients was associated with increased E/E' and compromised global longitudinal strain at 6 months compared to chemotherapy alone.
Why the study?
Anthracyclines and radiotherapy can both induce cardiotoxicity, but whether radiotherapy impacts cardiac function after prior anthracycline treatment in lymphoma patients remained to be investigated prospectively.
Does radiotherapy after anthracycline-based chemotherapy further impair cardiac function in lymphoma patients?
Population
22 eligible patients with Hodgkin or non-Hodgkin lymphomas treated with anthracyclines
Comparison
RT after chemotherapy vs chemotherapy only
Design
Prospective cohort study
Follow-up
6 months after treatment completion
Authors
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Supports enhanced monitoring of strain and diastolic function after combined therapy; leaves open causality and long-term outcomes.
Cohort (n=22)
Does radiotherapy after anthracycline-based chemotherapy further impair cardiac function in lymphoma patients?
In lymphoma patients treated with anthracyclines, the addition of radiotherapy is associated with further subclinical deterioration of cardiac function as detected by echocardiographic strain and diastolic parameters.
Mercurio et al. (2019) conducted a cohort in Hodgkin or non-Hodgkin lymphomas (n=22). Radiotherapy after chemotherapy vs. Chemotherapy only was evaluated on Cardiac function (ejection fraction, E/E', global longitudinal strain). Radiotherapy after anthracycline chemotherapy in lymphoma patients was associated with increased E/E' and compromised global longitudinal strain at 6 months compared to chemotherapy alone.
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