Key result
In head and neck cancer patients undergoing concurrent chemoradiotherapy with cisplatin, the incidence of thromboembolic events was 1.9%, with occurrence significantly associated with a higher Khorana score.
Why the study?
The study investigated the incidence of thromboembolic events and factors affecting their occurrence in head and neck cancer patients receiving concurrent chemoradiotherapy with cisplatin.
Cohort (n=257)
No
Answers are grounded in this paper and cite their sources.
The incidence of thromboembolic events in head and neck cancer patients receiving concurrent chemoradiotherapy with cisplatin is low (1.9%), but risk is significantly associated with a higher Khorana score.
BACKGROUND/AIMS: The study investigated the incidence of thromboembolic events (TEE) in head and neck (H&N) cancer patients who received concurrent chemoradiotherapy (CCRT) with cisplatin, and analyzed the factors affecting TEE occurrence. METHODS: Two hundred and fifty-seven patients who started CCRT with cisplatin for H&N cancer from January 2005 to December 2019 were analyzed. RESULTS: TEE occurred in five patients, an incidence rate of 1.9%. The 2-, 4-, and 6-month cumulative incidences of TEE were 0.8%, 1.6%, and 1.9%, respectively. Khorana score was the only factor associated with TEE occurrence (p = 0.010). CONCLUSION: The incidence of TEE in H&N cancer patients who underwent CCRT with cisplatin was relatively low when compared to other types of cancer. However, patients with a high Khorana score require more careful surveillance for possible TEE occurrence.
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Cho et al. (2022) conducted a cohort in Head and neck cancer (n=257). Concurrent chemoradiotherapy with cisplatin was evaluated on Incidence of thromboembolic events (TEE). In head and neck cancer patients undergoing concurrent chemoradiotherapy with cisplatin, the incidence of thromboembolic events was 1.9%, with occurrence significantly associated with a higher Khorana score.
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