Key result
ValveClamp implantation acutely altered 3D mitral valve geometry, with reductions in anterior-posterior diameter (p=0.008) and prolapse height (p=0.021) correlating with MR downgrading.
Why the study?
Few data are available about the specific impact of transcatheter edge-to-edge repair on mitral valve three-dimensional geometry in patients with degenerative mitral regurgitation.
Does ValveClamp implantation alter 3D mitral valve geometry and reduce mitral regurgitation in patients with degenerative mitral regurgitation?
Observational (n=35)
Does ValveClamp implantation alter 3D mitral valve geometry and reduce mitral regurgitation in patients with degenerative mitral regurgitation?
ValveClamp implantation acutely alters 3D mitral valve geometry, with reductions in anterior-posterior diameter and prolapse height correlating with decreased mitral regurgitation severity.
OBJECTIVES: We sought to assess the acute intraprocedural effects of the ValveClamp system in DMR patients on the mitral valve (MV) three-dimensional (3D) geometry and the association of these effects with mitral regurgitation (MR) reduction. BACKGROUND: Few data are available about the specific impact of transcatheter edge-to-edge repair in patients with degenerative mitral regurgitation (DMR). METHODS: Thirty-five symptomatic patients (age 74.26 ± 6.61 years) with Grade 3 to 4+ degenerative MR underwent 3D transoesophageal echocardiography (TEE) during ValveClamp implantation. Volumetric data sets were retrospectively analyzed using mitral valve quantitative 3D modeling software. RESULTS: to 1,013.44 ± 228.71 mm (p = .004). Accordingly, we observed a significant reduction of MR severity after ValveClamp implantation. Multivariable analysis revealed postprocedural MR reduction was associated with shortening in anterior-posterior diameter (coefficient 0.427, p = .008) and reduction in prolapse height (coefficient 0.369, p = .021). CONCLUSIONS: ValveClamp implantation exerts an acute effect on the 3D MV geometry. Postprocedural reduction in AP diameter and reduction in prolapse height correlates with MR downgrading in patients with degenerative MR.
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Ge et al. (2020) conducted an observational in Degenerative mitral regurgitation (n=35). ValveClamp system was evaluated on Acute intraprocedural effects on mitral valve 3D geometry and association with MR reduction. ValveClamp implantation acutely altered 3D mitral valve geometry, with reductions in anterior-posterior diameter (p=0.008) and prolapse height (p=0.021) correlating with MR downgrading.
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