Key result
Postoperative cardiac troponin I and T are linked to higher MACE risk after CABG.
Why the study?
The prognostic value and predictive performance of postoperative high-sensitive cardiac troponin I and T for MACE after CABG needed systematic evaluation.
Does postoperative cardiac troponin I and T measurement predict major adverse cardiac events in patients after coronary artery bypass grafting?
Systematic Review (n=7,571)
Does postoperative cardiac troponin I and T measurement predict major adverse cardiac events in patients after coronary artery bypass grafting?
Postoperative cardiac troponin I and T are associated with MACE after CABG, but current evidence is insufficient to support their routine use for clinical risk stratification due to moderate predictive performance and study heterogeneity.
Answers are grounded in this paper and cite their sources.
Does not support troponin-based MACE risk stratification after CABG; leaves open the need for prospective validation with standardized thresholds.
Background: This systematic review describes the prognostic value of postoperative cardiac high-sensitive troponin I and T as risk markers for major adverse cardiac events (MACE) after coronary artery bypass graft (CABG) surgery and their predictive performance. Methods: PubMed and Embase were searched up to 14 October 2024. Studies were included if they reported either the association between cardiac troponin I and T and MACE (using risk-, hazard-, or odds ratios) or the accuracy of troponin I and T based prediction models for MACE (using c-statistics and calibration) within 72 h after CABG. MACE was defined as the composite of myocardial infarction, coronary artery revascularisation, cardiac death, non-fatal cardiac arrest, and heart failure. Risk of bias was assessed using the Quality in Prognostic Studies tool. Risk of bias was moderate to high across domains. Conclusions: Postoperative cardiac troponin I and T biomarkers are associated with postoperative MACE after CABG. The current evidence on the predictive value for postoperative MACE is insufficient to use troponin I and T for risk stratification.
No takes yet. Share an insight, caveat, or question.
Thio et al. (2025) conducted a systematic review in Major adverse cardiac events (MACE) after coronary artery bypass grafting (CABG) (n=7,571). Postoperative cardiac troponin I and T was evaluated on Major adverse cardiac events (MACE). Postoperative cardiac troponin I and T were associated with higher risk of major adverse cardiac events after CABG, with HRs of 1.6-11.1 for cTnI and ORs of 0.9-67.9 for cTnT.
Synapse has enriched 10 related papers. Consider them for comparative context: