Key result
Increased postoperative troponin concentrations were associated with higher mid-term mortality after adult cardiac surgery (diagnostic OR 5.46; 95% CI 2.0-14.6).
Why the study?
Does increased postoperative troponin release predict mortality in adults after cardiac surgery?
Population
17 studies pooling up to 9,703 adult patients undergoing cardiac surgery.
Comparison
Increased postoperative troponin concentrations vs Normal or lower postoperative troponin…
Design
Meta-analysis
Follow-up
≥ 12 months
Authors
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May aid postoperative risk stratification after cardiac surgery; leaves open optimal thresholds due to assay heterogeneity.
Meta-Analysis (n=9,703)
Does increased postoperative troponin release predict mortality in adults after cardiac surgery?
Odds Ratio: 5.46 (95% CI 2–14.6)
Postoperative troponin release after adult cardiac surgery is significantly associated with both short-term and mid-term all-cause mortality, though assay and timing heterogeneity limit the establishment of definitive cut-offs.
Buse et al. (2009) conducted a meta-analysis in Adult cardiac surgery (CABG and valve surgery) (n=9,703). Increased postoperative troponin concentrations vs. Normal troponin concentrations was evaluated on Mid-term (≥ 12 months) all-cause mortality (diagnostic OR 5.46, 95% CI 2.0-14.6). Increased postoperative troponin concentrations were associated with higher mid-term mortality after adult cardiac surgery (diagnostic OR 5.46; 95% CI 2.0-14.6).