Key result
Radiofrequency catheter ablation caused delayed thrombogenesis, evidenced by significantly higher plasma TAT concentrations 3 days post-procedure compared to diagnostic EPS alone (21.3 vs 2.5 ng/ml).
Why the study?
Does radiofrequency catheter ablation cause delayed thrombogenesis compared to electrophysiologic study alone?
Population
63 patients
Comparison
Radiofrequency catheter ablation (RF-CA) vs Electrophysiologic study without ablation
Design
Cohort
Follow-up
6 days
Authors
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Association of ablation with delayed thrombogenesis warrants periprocedural caution; leaves open optimal antithrombotic duration and regimens for randomized confirmation.
Observational (n=63)
Yes
Does radiofrequency catheter ablation cause delayed thrombogenesis compared to electrophysiologic study alone?
Absolute Event Rate: 21.3% vs 2.5%
p-value: p=0.0003
Radiofrequency catheter ablation induces a biphasic thrombogenic response, with an acute phase related to catheter placement and a delayed phase at 3 days likely due to endothelial damage.
Sasano et al. (2002) conducted an observational in Supraventricular tachyarrhythmias (n=63). Radiofrequency catheter ablation (RF-CA) vs. Diagnostic electrophysiologic study (EPS) was evaluated on Plasma TAT concentration at 3 days post-procedure (ng/ml) (p=0.0003). Radiofrequency catheter ablation caused delayed thrombogenesis, evidenced by significantly higher plasma TAT concentrations 3 days post-procedure compared to diagnostic EPS alone (21.3 vs 2.5 ng/ml).
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