What question did this study set out to answer?

To assess the safety of radiofrequency ablation in the right atrium and the impact of heparin and aspirin on thrombus prevention after the procedure.

October 1, 1994Pacing and Clinical Electrophysiology

Power and Temperature Guided Radiofrequency Catheter Ablation of the Right Atrium in Pigs

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Why the study?

Does a single dose of intravenous heparin followed by aspirin reduce thrombus formation after radiofrequency catheter ablation of the right atrium in pigs?

Population

20 pigs undergoing radiofrequency catheter ablation of the right atrium

Comparison

Single dose of intravenous heparin followed by… vs Control group (no heparin/aspirin)

Design

Preclinical, Randomized to power or temperature guided unipolar RF catheter…

Follow-up

5-7 days

Authors

EKErik KongsgaardOslo University Hospital AFA. FoersterTechnische Universität Dresden HAHalfdan AassOslo University Hospital

Discussion

Member takes

Implication

May reduce post-ablation thrombus in pigs; hypothesis-generating for human trials.

Key Points

To assess the safety of radiofrequency ablation in the right atrium and the impact of heparin and aspirin on thrombus prevention after the procedure.
Twenty pigs were randomized to power or temperature guided RF catheter ablation.
Ten pigs received a heparin bolus followed by daily aspirin, while ten served as controls.
Transmural pressure resistance was assessed post-ablation through thoracotomy and cuff inflation.
Transmural lesions were successfully created in all animals without perforation, with right atrial pressure increased from 5 to 30 mmHg.
1-3 lung lesions were identified in 55% of animals, corresponding in localization to the atrial lesions.
Four thrombus formations were noted in the treatment group versus nine in controls, indicating a significantly lower incidence in the heparin/aspirin group.

Structured PICO

Does a single dose of intravenous heparin followed by aspirin reduce thrombus formation after radiofrequency catheter ablation of the right atrium in pigs?

Population

20 pigs undergoing radiofrequency catheter ablation of the right atrium

Intervention

Single dose of intravenous heparin (150 U/kg bolus) followed by aspirin (150 mg daily) after power or temperature guided unipolar RF catheter ablation

Comparator

Control group (no heparin/aspirin)

Outcome

Safety of ablating the atrial free wall (resistance to increased transmural pressure) and incidence of thrombus formationsafety

In a porcine model, a single dose of intravenous heparin followed by daily aspirin significantly reduced thrombus formation after right atrial RF ablation, though collateral lung injury was frequently observed.

Cite This Study

Kongsgaard et al. (1994) studied this question.

synapsesocial.com/papers/6a71a6aafe4101aa97e0a39b https://doi.org/10.1111/j.1540-8159.1994.tb02354.x

Topics

AF ablation outcomes

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Power and Temperature Guided Radiofrequency Catheter Ablation of the Right Atrium in Pigs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Power and Temperature Guided Radiofrequency Catheter Ablation of the Right Atrium in Pigs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider