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June 2, 1993European Heart Journal

The effect of temperature-guided radiofrequency ablation of ventricular myocardium

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Key result

Temperature-guided radiofrequency ablation in a beating porcine heart showed a positive correlation between lesion size and peak temperature in bipolar mode (r=0.48-0.56, P<0.05).

Why the study?

Does temperature-guided radiofrequency ablation produce predictable lesion sizes in an open-chest pig model?

Population

19 pigs in an open-chest animal model

Design

Preclinical

Authors

EKErik KongsgaardOslo University HospitalAFA. FoersterTechnische Universität DresdenHAHalfdan AassOslo University Hospital

Discussion

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Implication

May support temperature guidance in bipolar RF ablation; leaves open predictability in unipolar clinical use.

Structured PICO

Does temperature-guided radiofrequency ablation produce predictable lesion sizes in an open-chest pig model?

P
Population
19 pigs in an open-chest animal model
I
Intervention
Temperature-guided radiofrequency (RF) ablation of ventricular myocardium (bipolar or unipolar, 2 or 4 mm tip electrode, set temperature 60-90 degrees C, 30 s pulse duration)
O
Outcome
Safety and feasibility (lesion size, correlation with temperature/energy, histological examination)surrogate

Main Result

Effect estimate: correlation coefficient 0.48 and 0.56

p-value: p=<0.05

In a beating heart pig model, it is difficult to predict RF ablation lesion size from temperature or energy, particularly in unipolar configuration.

Cite This Study

Kongsgaard et al. (1993) studied Ventricular myocardium ablation (n=19). Temperature-guided radiofrequency ablation was evaluated on Correlation between lesion area/volume and peak temperature (correlation coefficient 0.48 and 0.56, p=<0.05). Temperature-guided radiofrequency ablation in a beating porcine heart showed a positive correlation between lesion size and peak temperature in bipolar mode (r=0.48-0.56, P<0.05).

synapsesocial.com/papers/6a12fcd3c031bb6829a7a929https://doi.org/10.1093/eurheartj/14.6.852

Topics

AF ablation outcomes
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tissue Heating During Radiofrequency Catheter Ablation: A Thermodynamic Model and Observations in Isolated Perfused and Superfused Canine Right Ventricular Free Wall1989 · 439 citations
  2. 2Radiofrequency coagulation of ventricular myocardium: Improved prediction of lesion size by monitoring catheter tip temperature1989 · 123 citations
  3. 3Radiofrequency lesions produced by handheld temperature controlled probes for use in atrial fibrillation surgery2001 · 12 citations
  4. 4Lesion Size in Relation to Ablation Site During Radiofrequency Ablation1998 · 23 citations
  5. 5Analysis of Catheter-Tip (8-mm) and Actual Tissue Temperatures Achieved During Radiofrequency Ablation at the Orifice of the Pulmonary Vein2004 · 72 citations