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Abstract After removal of SRBC rosette‐forming T‐cells from the peripheral blood, the residual, largely B‐lymphocyte fractin of five infectious mononucleosis patients was found no contain 0.5‐2% blast cells, positive for the EBV‐determined nuclear antigen (EBNA). There was a rough parallelism between the presence of large lymphoblasts in the hematological smear, EBNA‐positive large blasts in the B‐cell fraction and the ability of the T‐cell fraction to expert an EBV‐specific lymphocytotoxicity on established cell lines in vitro. EBNA‐positive B‐cells and EBV‐specific killer T‐cells disappeared after the acute phase of the disease.
Klein et al. (Thu,) studied this question.