What question did this study set out to answer?

To quantify and validate shared dimensional autistic phenotypes across schizophrenia and autism spectrum disorder to establish a framework for future biological pathway analyses.

May 12, 2015BMC PsychiatryOpen Access

Autism beyond diagnostic categories: characterization of autistic phenotypes in schizophrenia

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Authors

AKAnne KästnerAix-Marseille Université MBMartin BegemannMax Planck Institute of Experimental Medicine TMTanja Maria MichelUniversity of Southern Denmark

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Implication

Validation study uncovers shared autistic phenotypes in schizophrenia and autism spectrum disorder, highlighting a continuous behavioral spectrum across diagnostic boundaries.

Key Points

To quantify and validate shared dimensional autistic phenotypes across schizophrenia and autism spectrum disorder to establish a framework for future biological pathway analyses.
Extracted and summed specific items from the Positive and Negative Syndrome Scale to create the dimensional Positive and Negative Syndrome Scale Autism Severity Score (PAUSS) in a schizophrenia cohort (N = 1156).
Validated PAUSS against the Autism Diagnostic Observation Schedule (ADOS), Autism Quotient (AQ), and Empathy Quotient (EQ) in adults with high-functioning autism spectrum disorder (N = 165) and disease controls.
PAUSS differentiated autism spectrum disorder, schizophrenia, and disease controls, with receiver operating characteristic area under the curve values of 0.8 for PAUSS and 0.9 for ADOS.
PAUSS scores correlated strongly with ADOS classifications, showing highest values at ADOS scores ≥12 and lowest values at ADOS scores <7, whereas AQ and EQ performed at chance level for predicting autism spectrum disorder.

Cite This Study

Kästner et al. (2015) studied this question.

synapsesocial.com/papers/6a1c254b01af05bf0da91b9b https://doi.org/10.1186/s12888-015-0494-x

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Implication

Validation study uncovers shared autistic phenotypes in schizophrenia and autism spectrum disorder, highlighting a continuous behavioral spectrum across diagnostic boundaries.

Autism beyond diagnostic categories: characterization of autistic phenotypes in schizophrenia

Discussion

Member takes

Implication

Key Points

Cite This Study

Autism beyond diagnostic categories: characterization of autistic phenotypes in schizophrenia

Discussion

Member takes

Implication

Key Points

Cite This Study

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