Key result
Inhaled iloprost improved 6-minute walk distance from 105 m to 264 m and decreased systolic pulmonary arterial pressure from 64 mmHg to 45 mmHg over six months in a patient with cor pulmonale.
Why the study?
Does inhaled iloprost improve clinical and hemodynamic outcomes in a patient with cor pulmonale and pulmonary hypertension associated with severe COPD and tuberculous destroyed lung?
Case Report (n=1)
No
Does inhaled iloprost improve clinical and hemodynamic outcomes in a patient with cor pulmonale and pulmonary hypertension associated with severe COPD and tuberculous destroyed lung?
Inhaled iloprost improved clinical, functional, and hemodynamic parameters in a patient with severe cor pulmonale and pulmonary hypertension secondary to tuberculous destroyed lung, suggesting it may be an alternative treatment for refractory cases.
Answers are grounded in this paper and cite their sources.
May suggest benefit in COPD-related cor pulmonale; hypothesis-generating and requires prospective trials before practice change.
Chronic obstructive pulmonary disease (COPD) is one of the causes of cor pulmonale. Cor pulmonale patients with pulmonary hypertension have a significant lower survival rate than patients without. However, there is no conclusive treatment options in cor pulmonale and pulmonary hypertension associated with COPD until now. We report a patient with cor pulmonale and pulmonary hypertension associated with severe form of COPD and tuberculous destroyed lung who achieved marked clinical, functional and echocardiographic hemodynamic improvements with inhaled iloprost for six months.
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Park et al. (2014) conducted a case report in Cor pulmonale and severe pulmonary hypertension associated with tuberculous destroyed lung (n=1). Inhaled iloprost was evaluated on Clinical, functional and echocardiographic hemodynamic improvements (6-minute walk test distance, WHO/NYHA class, systolic pulmonary arterial pressure). Inhaled iloprost improved 6-minute walk distance from 105 m to 264 m and decreased systolic pulmonary arterial pressure from 64 mmHg to 45 mmHg over six months in a patient with cor pulmonale.
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