What question did this study set out to answer?

To assess the efficacy of inhaled aerosolized iloprost in treating life-threatening pulmonary hypertension accompanied by progressive right-heart failure refractory to conventional therapy.

March 21, 2000Annals of Internal Medicine

Inhaled Iloprost To Treat Severe Pulmonary Hypertension: An Uncontrolled Trial

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To assess the efficacy of inhaled aerosolized iloprost in treating life-threatening pulmonary hypertension accompanied by progressive right-heart failure refractory to conventional therapy.
Open, uncontrolled, multicenter trial conducted across intensive care units and pulmonary clinics at six university hospitals in Germany (N=19).
Participants received aerosolized iloprost 6 to 12 times daily (50 to 200 µg/day) over 3 months.
Cardiovascular effects were evaluated using right-heart catheterization and 6-minute walk distance at baseline and after 3 months of treatment.
Six-minute walk distance improved by a mean of 148 m (95% CI, 4.5 to 282 m; P = 0.048) at 3 months, and NYHA functional class improved in 8 of 15 surviving patients.
Hemodynamic measurements in 12 patients confirmed selective pulmonary vasodilatation with minimal systemic blood pressure effects at baseline and at 3 months.
Four patients died during the initial 3 months (3 from right-heart failure, 1 from sepsis), and 7 patients remained on long-term therapy (mean 536 ± 309 days).

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Implication

Uncontrolled trial demonstrates improved exercise capacity and hemodynamics with inhaled iloprost in severe pulmonary hypertension, suggesting a therapy for refractory right-heart failure.

Cite This Study

Olschewski et al. (2000) studied this question.

synapsesocial.com/papers/6a81ff4c5d6bc1011b4cf512 https://doi.org/10.7326/0003-4819-132-6-200003210-00003

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Implication

Uncontrolled trial demonstrates improved exercise capacity and hemodynamics with inhaled iloprost in severe pulmonary hypertension, suggesting a therapy for refractory right-heart failure.

Inhaled Iloprost To Treat Severe Pulmonary Hypertension: An Uncontrolled Trial

Key Points

Discussion

Implication

Cite This Study

Inhaled Iloprost To Treat Severe Pulmonary Hypertension: An Uncontrolled Trial

Key Points

Discussion

Implication

Cite This Study

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