Intravenous iloprost for treatment failure of aerosolised iloprost in pulmonary arterial hypertension: Table 1—
Why the study?
Does switching to continuous intravenous iloprost improve survival and exercise capacity in patients with severe PAH who deteriorate on aerosolised iloprost?
Population
16 patients with severe pulmonary arterial hypertension and severe right heart failure who experienced…
Design
Case_series
Authors
Discussion
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Member takes
Implication
May not change practice in deteriorating PAH; leaves open whether IV iloprost salvages outcomes in select patients.
Structured PICO
Does switching to continuous intravenous iloprost improve survival and exercise capacity in patients with severe PAH who deteriorate on aerosolised iloprost?
P
Population
16 patients with severe pulmonary arterial hypertension (PAH) and severe right heart failure who experienced primary or secondary treatment failure with aerosolised iloprost.
I
Intervention
Continuous intravenous iloprost
O
Outcome
Survival, New York Heart Association (NYHA) class, and walking distance in the 6-min walk testhard clinical
Switching to continuous intravenous iloprost can salvage clinical status and improve exercise capacity in about half of PAH patients who deteriorate on aerosolised iloprost, though it does not prevent progression in all patients.
Cite This Study
Hoeper et al. (2002) studied this question.