Ethnic Differences in Glycemic Markers in Patients With Type 2 Diabetes
Authors
Discussion
Loading...
Member takes
Implication
Clinical trial analysis demonstrates ethnic variations in hemoglobin A1c relative to blood glucose in type 2 diabetes, suggesting that clinical targets require ethnic adjustment.
Key Points
- To evaluate the relationship between HbA1c and self-monitored blood glucose across diverse ethnic cohorts and determine whether estimated average glucose accurately reflects glycemia.
- Evaluated 1,879 patients with type 2 diabetes aged 30 to 80 years across 11 countries in the DURABLE trial, categorized as Caucasian, Black, Asian, or Hispanic.
- Used logistic regression to model the relationship between mean 7-point self-monitored blood glucose profiles, HbA1c, and estimated average glucose by ethnic background.
- Baseline mean (SD) HbA1c was 9.0% (1.3) (75 [14] mmol/mol) and mean self-monitored blood glucose was 12.1 mmol/L (3.1) (217 [55] mg/dL).
- Within the HbA1c range of 7.0–9.0% (53–75 mmol/mol), non-Caucasian cohorts exhibited 0.2–0.5% (2–6 mmol/mol) higher HbA1c than Caucasians for equivalent blood glucose levels.
- Estimated average glucose overestimated actual blood glucose at mean levels ≤11.6 mmol/L and underestimated actual levels at >11.6 mmol/L.
Cite This Study
Wolffenbuttel et al. (2013) studied this question.