What does this research mean for the field?

Long-term intensified conventional insulin treatment in diabetes patients retards microangiopathy through improved glycemic control, but results in greater weight gain and a higher incidence of serious hypoglycemia compared to standard treatment. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1994Diabetes

Mortality and Treatment Side-Effects During Long-Term Intensified Conventional Insulin Treatment in the Stockholm Diabetes Intervention Study

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Why the study?

Does intensified conventional insulin treatment improve glycemic control and what are its side effects compared to standard treatment in patients with diabetes?

Population

102 patients with diabetes in the Stockholm Diabetes Intervention Study

Comparison

Intensified conventional insulin treatment (ICT) vs Standard treatment (ST)

Design

RCT, randomized

Follow-up

7.5 years

Authors

PRPer ReichardKarolinska Institutet MPM. PihlLinköping University

Discussion

Member takes

Implication

Weigh ICT benefits against hypoglycemia and weight gain risks; confirms the efficacy-safety balance in long-term diabetes RCTs.

Structured PICO

Does intensified conventional insulin treatment improve glycemic control and what are its side effects compared to standard treatment in patients with diabetes?

Population

102 patients with diabetes in the Stockholm Diabetes Intervention Study

Intervention

Intensified conventional insulin treatment (ICT)

Comparator

Standard treatment (ST)

Outcome

Mortality and treatment side-effects (including HbA1c reduction, weight change, atherosclerosis, myocardial infarction, ketoacidosis, and hypoglycemia)

Long-term intensified conventional insulin treatment significantly improves glycemic control but increases the risk of serious hypoglycemia and weight gain compared to standard treatment.

Cite This Study

Reichard et al. (1994) studied this question.

synapsesocial.com/papers/6a1c276bd54006be995fa2c4 https://doi.org/10.2337/diab.43.2.313

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Mortality and Treatment Side-Effects During Long-Term Intensified Conventional Insulin Treatment in the Stockholm Diabetes Intervention Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mortality and Treatment Side-Effects During Long-Term Intensified Conventional Insulin Treatment in the Stockholm Diabetes Intervention Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider