The values of log 10 P (partition coefficient, in octanol/water) were calculated for about 200 organic molecules of diverse structures and functionalities. The method involves a simple procedure and appears accurate enough for semiquantitative applications. Further, this method of calculating log 10 P values was shown to be successful in providing a better quantitative structure activity relationship ( QSAR ) than the Hansch‐type approach in the study of inhibitory activity of substituted phenols on Bacillus Subtilis spore germination.
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Klopman et al. (1985) studied this question.
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