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November 1, 1994Annals of Neurology

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

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Authors

PMPatrizia MecocciUniversity of PerugiaUMUsha MacGarveyMassachusetts General HospitalMBM. Flint BealBoston University

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Mecocci et al. (1994) studied this question.

synapsesocial.com/papers/6a1c2b1e01af05bf0da91e56https://doi.org/10.1002/ana.410360510
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain1993 · 764 citations
  2. 2Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents1984 · 948 citations
  3. 3Prevalence of Alzheimer's Disease in a Community Population of Older Persons1989 · 1,226 citations
  4. 4Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria. A model for post-ischemic and toxic mitochondrial damage.1986 · 257 citations
  5. 5The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen1973 · 2,630 citations