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November 1, 1997Infection and ImmunityOpen Access

Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock

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Authors

FMFrank MattnerAFFiRiS (Austria)LOLaurence OzmenRoche (Switzerland)FPFrank PodlaskiStevens Institute of Technology

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Mattner et al. (1997) studied this question.

synapsesocial.com/papers/6a1c2cdaea84844e355f8cafhttps://doi.org/10.1128/iai.65.11.4734-4737.1997
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice.1991 · 296 citations
  2. 2Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha1992 · 301 citations
  3. 3In vivo production and function of IL-12 p40 homodimers1997 · 232 citations
  4. 4Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice1995 · 472 citations
  5. 5Interleukin‐12 Antagonist Activity of Mouse Interleukin‐12 p40 Homodimer in Vitro and in Vivo1996 · 139 citations