Key result
Active cancer (OR 2.70; 95% CI 1.03-7.01), dementia (OR 2.69; 95% CI 1.53-4.74), and high urea and RDW at admission were independent predictors of one-year mortality after acute heart failure.
Why the study?
One-year mortality after hospitalization for heart failure is high, prompting this study to identify predictive factors of one-year mortality.
Observational (n=429)
No
Active cancer, dementia, and high values for urea and RDW at admission are independent predictors of one-year mortality in patients hospitalized for acute heart failure.
May inform prognosis in acute HF admissions; leaves open whether targeting these factors improves survival.
One-year mortality after hospitalization for heart failure (HF) is high. This study aims to identify predictive factors of one-year mortality. This is a retrospective, single-center and observational study. All patients hospitalized for acute HF during one year were enrolled. A total of 429 patients were enrolled, mean age of 79 years. The in-hospital and one-year all-cause mortality rates were 7.9% and 34.3%, respectively. In the univariable analysis, the factors significantly associated with higher one-year mortality risk were: age ≥80 years (odds ratio (OR)=2.05, 95% confidence interval (CI) 1.35–3.11, p=0.001); active cancer (OR=2.93, 95% CI 1.36–6.32, p=0.008); dementia (OR=2.84, 95% CI 1.81–4.47, p<0.001); functional dependency (OR=2.63, 95% CI 1.65–4.19, p<0.001); atrial fibrillation (OR=1.86, 95% CI 1.24–2.80, p=0.004); higher creatinine (OR=2.03, 95% CI 1.29–3.21, p=0.002), urea (OR=2.92, 95% CI 1.95–4.36, p<0.001) and red cell distribution width (RDW; 4thQ OR=5.59, 95% CI 3.03–10.32, p=0.001); and lower hematocrit (OR=0.94, 95% CI 0.91–0.97, p<0.001), hemoglobin (OR=0.83, 95% CI 0.75–0.92, p<0.001) and platelet distribution width (PDW; OR=0.89, 95% CI 0.82–0.97, p=0.005). In the multivariable analysis, the independent predictors of higher one-year mortality risk were: age ≥80 years (OR=2.05, 95% CI 1.21–3.48); active cancer (OR=2.70, 95% CI 1.03–7.01); dementia (OR=2.69, 95% CI 1.53–4.74); higher urea (OR=2.97, 95% CI 1.84–4.80) and RDW (4thQ OR=5.24, 95% CI 2.55–10.76); and lower PDW (OR=0.88, 95% CI 0.80–0.97). Active cancer, dementia, and high values for urea and RDW at admission are predictors of one-year mortality in patients hospitalized for HF. These variables are readily available at admission and can support the clinical management of HF patients. A mortalidade no primeiro ano após a hospitalização por insuficiência cardíaca é alta. Este estudo tem como objetivo identificar fatores preditivos de mortalidade nesse período. Este é um estudo retrospetivo e observacional de um só centro. Todos os doentes hospitalizados por insuficiência cardíaca aguda durante o período de um ano foram incluídos. Foram incluídos 429 doentes com idade média de 79 anos. As taxas de mortalidade intra-hospitalar e por todas as causas após um ano foram de 7,9% e 34,3%, respetivamente. Na análise univariável, os fatores significativamente associados com maior risco de mortalidade a um ano foram: idade ≥ 80 anos (OR=2,05, IC 95% 1,35-3,11, p=0,001); neoplasia ativa (OR=2,93, IC 95% 1,36-6,32, p=0,008); demência (OR=2,84, IC 95% 1,81-4,47, p<0,001); dependência funcional (OR=2,63, IC 95% 1,65-4,19, p<0,001); fibrilhação auricular (OR=1,86, IC 95% 1,24-2,80, p=0,004); valores elevados de creatinina (OR=2,03, IC 95% 1,29-3,21, p=0,002), ureia (OR=2,92, IC 95% 1,95-4,36, p<0,001) e índice de distribuição de eritrócitos (RDW; 4Q OR=5,59, IC 95% 3,03-10,32, p=0,001); e valores baixos de hematócrito (OR=0,94, IC 95% 0,91-0,97, p<0,001), hemoglobina (OR=0,83, IC 95% 0,75-0,92, p<0,001) e índice de distribuição de plaquetas (PDW; OR=0,89, IC 95% 0,82-0,97, p=0,005). Na análise multivariável, os preditores independentes de maior risco de mortalidade a um ano foram: idade ≥ 80 anos (OR=2,05, IC 95% 1,21-3,48); neoplasia ativa (OR=2,70, IC 95% 1,03-7,01); demência (OR=2,69, IC 95% 1,53-4,74); ureia elevada (OR=2,97, IC 95% 1,84-4,80) e RDW (4Q OR=5,24, IC 95% 2,55-10,76); e PDW baixo (OR=0,88, IC 95% 0,80-0,97). Neoplasia ativa, demência e valores elevados de ureia e RDW na admissão são preditores de mortalidade após um ano dos doentes hospitalizados por insuficiência cardíaca. Estes dados estão facilmente disponíveis na admissão e podem auxiliar na gestão clínica de doentes com insuficiência cardíaca.
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Marques et al. (2023) conducted an observational in acute heart failure (n=429). Predictive risk factors (e.g., active cancer, dementia, urea, RDW) was evaluated on one-year all-cause mortality. Active cancer (OR 2.70; 95% CI 1.03-7.01), dementia (OR 2.69; 95% CI 1.53-4.74), and high urea and RDW at admission were independent predictors of one-year mortality after acute heart failure.
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