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luciferase reporter assay. This revealed 30-fold less cytotoxicity, a much wider viable concentration range, and a 2-fold greater transfection efficiency for the PVAm copolymer compared to lPEI. This study provides insights into the PI-RAFT copolymerization of the less activated monomers NVF and NVP and highlights the potential of polyvinyl amine copolymers resulting from selective hydrolysis for the transfection of genetic material compared with lPEI.
Fielitz et al. (Fri,) studied this question.