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Introduction The first purpose of this research has been to identify the organs and tissues which are affected by the various causes of exhaustion. It is at once obvious that these do not include the skin, the tendons, the connective tissue, the fat, the bones, the cartilage, the teeth, the hair, the organs of the digestive system or of the genito-urinary system, the lymphatic vessels or glands, the spleen, the sweat glands, the pancreas or the organs of common sensation. The organs and tissues in which one would expect to find signs of exhaustion are organs that are essential to life within the period of death from acute exhaustion. The second purpose has been to ascertain whether or not all the known causes of exhaustion produce identical end-effects in the essential organs. That is to say, do insomnia, infection, exertion, emotion, asphyxia, exophthalmic goiter, iodism, anesthesia, the excision of organs,
G. W. Crile (Tue,) studied this question.