Key result
A review of cardiac histology and embryogenesis highlights the inherent difficulties remaining in identifying effective cell populations for cell-based myocardial regeneration therapy.
Answers are grounded in this paper and cite their sources.
Provides an overview of heart histology and embryogenesis to inform the development and assessment of cell-based therapies for myocardial regeneration.
Cardiac regeneration in the form of cell-based therapy offers hope of becoming the breakthrough technology that transforms the state of cardiac medicine. Before attempting to develop the techniques to assess the effectiveness of myocardial regeneration in humans, researchers must have at least a basic understanding of the human heart in its embryonic, normal, and diseased states. To this end, we provide an overview of the histology of the heart, including the current theories on normal embryogenesis and the histology of normal and ischemic myocardium as visualized by pathologists. Knowledge of the cellular constituents, including the controversial existence of resident cardiac stem and/or progenitor cells, and their actions and interactions in the normal state and under the conditions of myocardial ischemia is also crucial before embarking on the quest for cardiac regeneration. Despite widespread optimism in the success of cell-based therapy, inherent difficulties remain in the identification of effective cell populations proposed for cell-based therapy in the human heart.
No takes yet. Share an insight, caveat, or question.
Carter‐Monroe et al. (2010) conducted a review in Myocardial regeneration. Cell-based therapy was evaluated. A review of cardiac histology and embryogenesis highlights the inherent difficulties remaining in identifying effective cell populations for cell-based myocardial regeneration therapy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: