December 1, 1998AJP Heart and Circulatory PhysiologyOpen Access

Effects of aging on sarcoplasmic reticulum Ca²⁺-cycling proteins and their phosphorylation in rat myocardium

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Population

Homogenates and sarcoplasmic reticulum vesicles derived from the ventricular myocardium of adult and aged…

Comparison

Aging (aged 26-28 months old rats) vs Adult (6-8 months old) rats

Design

Preclinical

Authors

AXAlex XuUniversity Hospitals of Cleveland NNNjanoor NarayananJSS Academy of Higher Education and Research

Discussion

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Implication

Hypothesis-generating for CaMKII-related diastolic changes in aging; leaves open human translation and therapeutic targeting.

Structured PICO

Population

Homogenates and sarcoplasmic reticulum (SR) vesicles derived from the ventricular myocardium of adult (6-8 months old) and aged (26-28 months old) Fischer 344 rats

Intervention

Aging (aged 26-28 months old rats)

Comparator

Adult (6-8 months old) rats

Outcome

Contents of major SR Ca2+-cycling proteins and SR protein phosphorylation by endogenous Ca2+/calmodulin-dependent protein kinase (CaM kinase)surrogate

Aging in rat myocardium is associated with reduced CaM kinase-mediated phosphorylation of SR Ca2+-cycling proteins and impaired Ca2+ uptake, which may contribute to the age-related slowing of cardiac muscle relaxation.

Cite This Study

Xu et al. (1998) studied this question.

synapsesocial.com/papers/6a1c39cc4cc49ccc94a91874 https://doi.org/10.1152/ajpheart.1998.275.6.h2087

View Full Paper

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Effects of aging on sarcoplasmic reticulum Ca²⁺-cycling proteins and their phosphorylation in rat myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of aging on sarcoplasmic reticulum Ca²⁺-cycling proteins and their phosphorylation in rat myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider