Aging in rat myocardium is associated with reduced CaM kinase-mediated phosphorylation of SR Ca2+-cycling proteins and impaired Ca2+ uptake, which may contribute to the age-related slowing of cardiac muscle relaxation.
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Hypothesis-generating for CaMKII-related diastolic changes in aging; leaves open human translation and therapeutic targeting.
Xu et al. (1998) studied this question.
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