Key result
Senescence in male rats is associated with a 28-44% slower rate of cardiac sarcoplasmic reticulum calcium uptake (P<0.05), primarily due to a 22% lower content of CaATPase protein.
Population
11- to 12-mo-old (adult) and 22- to 24-mo-old (senescent) male Fischer 344 rats
Comparison
Senescence (aging to 22-24 months) vs Adult (11-12 months old) rats
Design
Preclinical
Authors
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Hypothesis-generating for CaATPase in rodent cardiac senescence; leaves open relevance to human diastolic dysfunction.
p-value: p=< 0.05
The age-related decline in calcium transport by cardiac sarcoplasmic reticulum is primarily driven by a reduced content of the CaATPase protein.
Taffet et al. (1993) studied Aging (Senescence). Senescence (aging) vs. Adult (11-12 months old) rats was evaluated on Rate of calcium uptake by homogenate and isolated SR (p=< 0.05). Senescence in male rats is associated with a 28-44% slower rate of cardiac sarcoplasmic reticulum calcium uptake (P<0.05), primarily due to a 22% lower content of CaATPase protein.
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