Key result
Short-term atorvastatin therapy (20 mg/day for 8 weeks) significantly reduced pulse wave velocity from 8.43 to 7.42 m/s (p=0.002) in SLE patients with baseline pathological arterial stiffness.
Why the study?
Does short-term atorvastatin therapy improve arterial stiffness in female patients with systemic lupus erythematosus?
Observational (n=37)
Does short-term atorvastatin therapy improve arterial stiffness in female patients with systemic lupus erythematosus?
Absolute Event Rate: 7.42% vs 8.43%
p-value: p=0.002
Short-term low-dose atorvastatin therapy significantly reduces arterial stiffness and improves surrogate markers of subclinical atherosclerosis in female patients with systemic lupus erythematosus.
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May support short-term atorvastatin for arterial stiffness in SLE; leaves open randomized confirmation of outcomes.
Castejón et al. (2016) conducted an observational in Systemic lupus erythematosus (SLE) (n=37). Atorvastatin vs. Baseline was evaluated on Carotid-femoral pulse wave velocity (PWV) in patients with baseline pathological arterial stiffness (p=0.002). Short-term atorvastatin therapy (20 mg/day for 8 weeks) significantly reduced pulse wave velocity from 8.43 to 7.42 m/s (p=0.002) in SLE patients with baseline pathological arterial stiffness.
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