The discovery by Nirenberg and Matthaei in 1961 that synthetic polyribonucleotides could function as messengers in a cell-free system has provided researchers with a very powerful new approach in the study of protein synthesis. Our own work in this field has been directed into two major channels: the first of these has been the development of new methods for the synthesis of oligonucleotides of defined sequence; the second has been the study of the coding properties of these oligonucleotides.
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Thach et al. (1966) studied this question.