Radical resection of urological malignancies in patients with liver cirrhosis significantly increased the mean Child-Pugh score, and a postoperative downgrade in classification was associated with worse overall survival.
Cohort (n=69)
No
Does radical resection for urological malignancies impact Child-Pugh classification and survival in patients with liver cirrhosis?
In patients with liver cirrhosis undergoing radical surgery for urological malignancies, postoperative deterioration of Child-Pugh classification is a significant predictor of worse survival outcomes.
Effect estimate: HR 2.671 (95% CI 1.238-5.760)
p-value: p=0.012
Objective Patients with liver cirrhosis often present with relative contraindications to surgery, such as impaired coagulation function and thrombocytopenia. Methods A total of 69 patients with urinary system malignancies who underwent radical resection under general anesthesia in the urology department of our hospital between 2013 and 2025 were included in this study. A Wilcoxon rank sum test was conducted to evaluate changes in the Child–Pugh(CP) classification before and after general anesthesia in patients with urinary system malignancies complicated by liver cirrhosis. The Pearson chi-square test was employed to assess the impact of various liver cirrhosis-related factors on the likelihood of CP classification downgrade. Results A total of 54 patients were classified as CP grade A prior to surgery. For patients with malignant tumors of urology combined with cirrhosis, the mean CP score ( P 0.0001) increased before and after surgery. There was no statistically significant effect of various liver cirrhosis-related factors on deterioration in the CP classification ( P = 0.072). Univariate and multivariate analyses demonstrated that CP classification downgrading was significantly associated with overall survival (OS) ( P = 0.006), cancer-specific survival (CSS) ( P = 0.028), and disease-free survival (DFS) ( P = 0.039). Compared with patients with a downgraded CP classification, patients without a downgraded CP classification had a more favorable survival curve (OS, P = 0.0034; CSS, P = 0.0194; DFS, P = 0.0296). Conclusion Surgery for malignant urinary system tumors in patients with CP grades A and B is generally considered safe. However, in some cases, the procedure may result in an elevated CP score and a downgrade in classification.
Wang et al. (Wed,) conducted a cohort in Urinary system malignancies complicated by liver cirrhosis (n=69). Radical resection under general anesthesia vs. Patients without a downgraded Child-Pugh classification was evaluated on Overall survival (OS) based on Child-Pugh classification downgrade (HR 2.671, 95% CI 1.238-5.760, p=0.012). Radical resection of urological malignancies in patients with liver cirrhosis significantly increased the mean Child-Pugh score, and a postoperative downgrade in classification was associated with worse overall survival.