Why the study?
Physicians' adherence to guideline-recommended HF treatment remains suboptimal, particularly regarding target doses and among non-cardiologists, likely compromising survival, readmissions, and quality of life.
This guidance document emphasizes the urgent need to transition from a sequential approach to a rapid, combined initiation and uptitration of the four foundational pillars of heart failure therapy to improve patient outcomes.
Clinicians should prioritize rapid combined four-pillar GDMT initiation now; extends sequential paradigms with practical titration protocols for broader providers.
Physicians' adherence to guideline-recommended heart failure (HF) treatment remains suboptimal, especially regarding the target doses. In particular, there is evidence that non-cardiologists are less compliant with HF guideline recommendations. This is likely to have a detrimental impact on patients' survival, readmissions and quality of life. Thus, the present document aims to address the reasons underlying low implementation and under-dosing of guideline-directed medical therapy in HF and to update a guidance for the initiation and rapid titration of HF drugs. In particular, aim of this document is to provide practical indications for drug implementation, to be applied not only by cardiologists but also by GPs and internal medicine doctors.
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Volterrani et al. (2024) conducted a review in Heart failure. Guideline-directed medical therapy (GDMT) was evaluated. This review provides updated practical guidance for the initiation and rapid titration of guideline-directed medical therapy in patients with heart failure to address suboptimal implementation.
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