Key result
Rational use of NSAIDs requires considering risk factors and using proton pump inhibitors to prevent gastrointestinal complications, as no effective medications exist for kidney and liver protection.
Why the study?
NSAIDs can cause a wide range of adverse reactions posing serious risks to patients, necessitating rational use and effective prevention strategies for drug complications based on predicted side effects and modern algorithms.
Rational use of NSAIDs requires careful selection based on risk factors and use of PPIs for GI protection, though kidney and liver risks remain unmitigated.
May inform risk-stratified NSAID prescribing with PPI gastroprotection; leaves open reno- and hepatoprotective strategies.
Non-steroidal anti-inflammatory drugs (NSAIDs) are included in a pharmacological group of drugs with different chemical structures providing anti-inflammatory, analgesic and antipyretic actions, as well as antiplatelet action to a certain degree. Unfortunately, NSAIDs can cause a wide range of adverse reactions (AR) posing a serious risk to the health and life of patients. Therefore, the rational use of NSAIDs should include methods for effective prevention of drug complications. Many NSAIDs have a pronounced therapeutic effect, simultaneously causing many undesirable effects, so the drug shall be chosen considering the development of predicted side effects and modern algorithms. According to clinical recommendations, risk factors and administration of safer NSAIDs shall be considered as the main prevention method. Besides, it is possible to protect the patient from the upper gastrointestinal tract complications using proton pump inhibitors. It should be noted that there are no effective medication methods for kidney and liver protection to reduce the risk of NSAID-associated complications.
No takes yet. Share an insight, caveat, or question.
Максимов et al. (2020) conducted a review in Adverse reactions to NSAIDs. Non-steroidal anti-inflammatory drugs (NSAIDs) was evaluated. Rational use of NSAIDs requires considering risk factors and using proton pump inhibitors to prevent gastrointestinal complications, as no effective medications exist for kidney and liver protection.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: