Key result
First-trimester fetal echocardiography detects ~55% of all congenital heart defects and identifies all severe cases.
Why the study?
The study was conducted to evaluate the diagnostic performance of standardized first trimester fetal echocardiography for the detection of congenital heart defects.
Does standardized first trimester fetal echocardiography accurately detect congenital heart defects in pregnant women?
Observational (n=311)
No
Does standardized first trimester fetal echocardiography accurately detect congenital heart defects in pregnant women?
Standardized first trimester fetal echocardiography is highly accurate for detecting severe congenital heart defects, though second trimester screening remains necessary due to its low sensitivity for mild defects.
May support severe defect detection in selected cohorts; leaves open generalizability and requires prospective validation before wider use.
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Akalın et al. (2025) conducted an observational in Congenital heart defects (n=311). Standardized first trimester fetal echocardiography vs. Postnatal echocardiography (reference standard) was evaluated on Diagnostic sensitivity for overall congenital heart defects (54.5% sensitivity, 100% specificity). Standardized first trimester fetal echocardiography demonstrated 54.5% sensitivity and 100% specificity for overall congenital heart defects, while achieving 100% sensitivity and 100% specificity for severe defects.
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