Key result
In the absence of randomized controlled trials, the management of postural orthostatic tachycardia syndrome relies on a stepwise approach of nonpharmacological and pharmacological therapies for symptom control.
Why the study?
Long-term, multicenter, randomized controlled trial data are lacking for the management of postural orthostatic tachycardia syndrome.
This review provides a structured, step-wise framework for the management of POTS using nonpharmacological and pharmacological therapies based on available observational evidence.
May guide stepwise POTS symptom management now; leaves open need for RCTs to confirm efficacy.
Postural orthostatic tachycardia syndrome (POTS) is a clinical syndrome causing patients to experience light-headedness, palpitations, tremors, and breathlessness upon assuming an upright posture. Despite the absence of available long-term, multicenter, randomized controlled trial data, this literature review aims to concisely present the nonpharmacological and pharmacological interventions that have been used in the treatment of POTS reported to date by cross-sectional studies, cohort studies, and retrospective studies. We attempt to classify treatments as first-, second-, and third-line therapies based on our own experience and available data.
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Kichloo et al. (2021) conducted a review in Postural Orthostatic Tachycardia Syndrome (POTS). Nonpharmacological and pharmacological therapies was evaluated. In the absence of randomized controlled trials, the management of postural orthostatic tachycardia syndrome relies on a stepwise approach of nonpharmacological and pharmacological therapies for symptom control.