Key result
Higher V2 T-wave amplitude linked to ~26% lower aborted sudden cardiac arrest risk in HCM.
Why the study?
Does T-wave amplitude predict aborted sudden cardiac arrest in high-risk patients with hypertrophic cardiomyopathy?
Cohort (n=52)
Single-blind (outcome assessor)
No
Does T-wave amplitude predict aborted sudden cardiac arrest in high-risk patients with hypertrophic cardiomyopathy?
Hazard Ratio: 0.74 (95% CI 0.57–0.97)
p-value: p=0.03
Reduced T-wave amplitude on surface ECG is an independent predictor of aborted sudden cardiac arrest in high-risk patients with hypertrophic cardiomyopathy, providing incremental prognostic value to traditional risk factors.
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May refine SCA risk stratification in HCM; leaves open prospective validation beyond established scores.
Sugrue et al. (2017) conducted a cohort in Hypertrophic cardiomyopathy (n=52). T-wave amplitude vs. Higher T-wave amplitude was evaluated on Aborted sudden cardiac arrest (appropriate ICD discharge for ventricular arrhythmia or non-fatal VF/sustained VT) (adjusted HR 0.74, 95% CI 0.57 to 0.97, p=0.03). In patients with hypertrophic cardiomyopathy and an implanted defibrillator, reduced T-wave amplitude in lead V2 was an independent predictor of aborted sudden cardiac arrest (adjusted HR 0.74 per 0.1 mV).
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