Key result
Cardiac conduction is a complex, multifactorial process determined by cellular excitability, gap junctional conductance, tissue architecture, and potentially ephaptic coupling.
This review highlights the historical evolution and recent paradigm-shifting developments in the understanding of cardiac conduction mechanisms.
May inform arrhythmia risk stratification; leaves open ephaptic coupling's clinical role pending targeted studies.
Cardiac conduction is the process by which electrical excitation spreads through the heart, triggering individual myocytes to contract in synchrony. Defects in conduction disrupt synchronous activation and are associated with life-threatening arrhythmias in many pathologies. Therefore, it is scarcely surprising that this phenomenon continues to be the subject of active scientific inquiry. Here we provide a brief review of how the conceptual understanding of conduction has evolved over the last century and highlight recent, potentially paradigm-shifting developments.
No takes yet. Share an insight, caveat, or question.
Veeraraghavan et al. (2014) conducted a review in Cardiac conduction abnormalities. Cardiac conduction is a complex, multifactorial process determined by cellular excitability, gap junctional conductance, tissue architecture, and potentially ephaptic coupling.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: