Old cogs, new tricks: A scaffolding role for connexin43 and a junctional role for sodium channels?

Q: What is the clinical evidence from this study?

Study design: Review. Population: Cardiac conduction defects and arrhythmias.

Q: What does this research mean for the field?

Recent insights into cardiac myocyte intercalated disk ultrastructure suggest that electrical coupling between cardiac myocytes can occur ephaptically, without the direct transfer of ions between cells. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

Rengasayee Veeraraghavan; Steven Poelzing; Robert G. Gourdie

doi:10.1016/j.febslet.2014.01.026

January 28, 2014FEBS LettersOpen Access

Old cogs, new tricks: A scaffolding role for connexin43 and a junctional role for sodium channels?

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Key Points

This review explores the evolving understanding of cardiac conduction, focusing on the role of connexin43 and sodium channels in myocyte communication.
Review of recent literature on cardiac conduction mechanisms and intercalated disk ultrastructure.
Analysis of the ephaptic coupling hypothesis in cardiac myocytes.
Emerging evidence suggests that electrical coupling may occur without direct ionic transfer, supporting the ephaptic coupling hypothesis.
Insights into the ultrastructural organization of intercalated disks provide a new perspective on cardiac conduction processes.

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Population

Cardiac conduction defects and arrhythmias

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Implication

This review highlights recent insights into cardiac myocyte intercalated disk ultrastructure and the ephaptic coupling hypothesis for cardiac conduction.

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Cite This Study

Veeraraghavan et al. (2014) conducted a review in Cardiac conduction defects and arrhythmias.

synapsesocial.com/papers/6a155baf37103a43379f9cb5 https://doi.org/10.1016/j.febslet.2014.01.026

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Old cogs, new tricks: A scaffolding role for connexin43 and a junctional role for sodium channels?

Key Points

PICO

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Implication

Abstract

Discussion

Cite This Study

Old cogs, new tricks: A scaffolding role for connexin43 and a junctional role for sodium channels?

Key Points

PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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