Why the study?
Data from non-mammalian hearts, Cx43 knockout mice, and human Cx43 mutations raised questions about whether gap junctions are the sole means of electrical coupling between cardiomyocytes.
Population
Mammalian ventricles, non-mammalian hearts, Connexin 43 (Cx43) knockout mice, and human Cx43 mutations
Design
Review
Authors
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Refines conduction models in arrhythmia research; leaves open validation and therapeutic targeting in patients.
Cardiac electrical connectivity involves both electrotonic and ephaptic mechanisms facilitated by Cx43 gap junctions, offering new perspectives on arrhythmia mechanisms.
Robert G. Gourdie (2018) studied this question.
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