Key result
Comprehensive topographical mapping of the mouse atria revealed that sympathetic axon density varies considerably by region, with the greatest density of innervation found near the sinoatrial node.
Why the study?
The sympathetic nervous system is crucial for controlling multiple cardiac functions, but a comprehensive, detailed neuroanatomical map of the sympathetic innervation of the heart was unavailable.
Population
Whole atria of C57Bl/6 J mice
Design
Quantitative anatomical mapping study
Authors
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Regional sympathetic mapping in mouse atria may guide autonomic models; leaves open human translation and clinical relevance.
p-value: p=<0.05
Zhang et al. (2023) studied Healthy (n=20). Anatomical mapping was evaluated on Regional density of tyrosine hydroxylase-immunoreactive (TH-IR) axons (p=<0.05). Comprehensive topographical mapping of the mouse atria revealed that sympathetic axon density varies considerably by region, with the greatest density of innervation found near the sinoatrial node.
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