April 1, 1992Journal of Clinical InvestigationOpen Access

Direct contact between sympathetic neurons and rat cardiac myocytes in vitro increases expression of functional calcium channels.

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Population

Cultures of neonatal rat ventricular myocytes

Comparison

Direct contact with sympathetic ganglia vs Control cells without sympathetic ganglia and…

Design

Preclinical

Authors

SOSatoshi OgawaNational Institute of Technology, Niihama College JBJoey V. BarnettBrigham and Women's Hospital LSLuyi SenCurtin University

Discussion

Member takes

Implication

May modulate excitability in developing myocytes; leaves open relevance to adult human disease or arrhythmogenesis.

Structured PICO

Population

Cultures of neonatal rat ventricular myocytes

Intervention

Direct contact with sympathetic ganglia (innervation)

Comparator

Control cells without sympathetic ganglia and cells grown in conditioned medium

Outcome

Expression and function of cardiac Ca channels (assessed by contractility, dihydropyridine binding sites, and L-type Ca channel current density)surrogate

Direct physical contact between sympathetic neurons and neonatal rat ventricular myocytes increases the expression of functional L-type calcium channels.

Cite This Study

Ogawa et al. (1992) studied this question.

synapsesocial.com/papers/6a1c4ddf01af05bf0da92f06 https://doi.org/10.1172/jci115688

View Full Paper

Ask AI

Bookmark

Direct contact between sympathetic neurons and rat cardiac myocytes in vitro increases expression of functional calcium channels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Direct contact between sympathetic neurons and rat cardiac myocytes in vitro increases expression of functional calcium channels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider