Key result
Inhibition of potassium pathways using DAP, ouabain, or BaCl2 significantly reduced rapid arteriolar dilatation following a single muscle contraction by an average of 58.8% to 65.7%.
Population
Anaesthetized hamster cremaster preparation in situ
Comparison
Inhibitors of K+ source (3,4-diaminopyridine… vs Absence of inhibitors
Design
Preclinical
Authors
Loading...
Potassium mediates rapid contraction-induced vasodilation in animals; leaves open human relevance and clinical translation.
Potassium is involved in the rapid vasodilatation in response to a single muscle contraction across a wide range of stimulus frequencies.
Armstrong et al. (2007) studied this question. Potassium pathway inhibitors (DAP, ouabain, BaCl2) vs. Absence of inhibitors was evaluated on Change in diameter of arterioles at a site of overlap with stimulated muscle fibres (rapid dilatation at 4 s). Inhibition of potassium pathways using DAP, ouabain, or BaCl2 significantly reduced rapid arteriolar dilatation following a single muscle contraction by an average of 58.8% to 65.7%.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: