Key result
Transdermal oestradiol replacement for 1 month in postmenopausal women restored the normal blunting of sympathetic vasoconstriction during exercise (decrease in muscle oxygenation 2% vs 12% at baseline; P<0.05).
Why the study?
Does transdermal oestradiol replacement improve functional sympatholysis in exercising forearms of postmenopausal women?
Population
16 women (8 premenopausal and 8 postmenopausal)
Comparison
Transdermal oestradiol replacement for 1 month vs Baseline (pre-treatment) and premenopausal women
Design
Other
Follow-up
1 month
Authors
Loading...
May restore functional sympatholysis in postmenopausal women; leaves open clinical relevance and need for larger trials.
Does transdermal oestradiol replacement improve functional sympatholysis in exercising forearms of postmenopausal women?
Absolute Event Rate: 2% vs 12%
p-value: p=<0.05
Short-term transdermal oestradiol replacement restores normal functional sympatholysis in postmenopausal women, highlighting the role of oestrogen in sympathetic neural control of muscle haemodynamics during exercise.
Fadel et al. (2004) studied Oestrogen deficiency in postmenopausal women (n=16). Transdermal oestradiol replacement vs. Baseline (before oestradiol replacement) was evaluated on Decrease in muscle oxygenation in exercising forearm in response to lower body negative pressure (p=<0.05). Transdermal oestradiol replacement for 1 month in postmenopausal women restored the normal blunting of sympathetic vasoconstriction during exercise (decrease in muscle oxygenation 2% vs 12% at baseline; P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: