June 19, 2007Circulation
Coronary Artery Involvement in Children With Kawasaki Disease
Key result
In children with Kawasaki disease, maximum coronary artery z scores were greatest at baseline and diminished over time, with 26% having a maximal z score ≥2.5 at any time.
Why the study?
What are the patterns and risk factors for coronary artery involvement in children with Kawasaki disease when assessed by serial normalized z scores?
Population
190 children with Kawasaki disease
Design
Cohort
Follow-up
5 weeks
Authors
Discussion
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Implication
Supports baseline coronary assessment in Kawasaki disease; leaves open whether serial z-score monitoring refines risk stratification or outcomes.
Study Design
Type
Cohort (n=190)
Structured PICO
What are the patterns and risk factors for coronary artery involvement in children with Kawasaki disease when assessed by serial normalized z scores?
P
Population
190 children with Kawasaki disease
I
Intervention
Pulse steroids in addition to standard intravenous immunoglobulin
O
Outcome
Maximum coronary artery z score normalized to body surface area at baseline, 1 week, and 5 weekssurrogate
Serial normalized coronary artery z scores in Kawasaki disease are highest at baseline and decrease over time, with younger age and delayed treatment predicting worse involvement.
Cite This Study
McCrindle et al. (2007) conducted a cohort in Kawasaki disease (n=190). Pulse steroids and standard intravenous immunoglobulin was evaluated on Maximum coronary artery z score normalized to body surface area. In children with Kawasaki disease, maximum coronary artery z scores were greatest at baseline and diminished over time, with 26% having a maximal z score ≥2.5 at any time.