Key result
CRT shows benefit for dyssynchrony-associated HF in pediatric and congenital heart disease.
Why the study?
Does Cardiac Resynchronization Therapy improve outcomes in children and patients with congenital heart disease and heart failure?
Does Cardiac Resynchronization Therapy improve outcomes in children and patients with congenital heart disease and heart failure?
Emerging retrospective data and case series suggest that CRT may offer significant clinical and hemodynamic benefits in select pediatric and congenital heart disease patients with heart failure and ventricular dyssynchrony.
May support CRT consideration in select pediatric dyssynchrony-associated HF; leaves open need for prospective trials.
Cardiac Resynchronization therapy has become an important management tool in adults with heart failure and dilated cardiomyopathy. The role of CRT in children with CHF is still unclear. Evidence is slowly emerging in the pediatric cardiology literature that CRT may have an important and useful role in certain select populations with CHF. These include patients with complete heart block who develop pacing-induced cardiomyopathy, certain forms of congenital heart disease associated with systemic ventricular failure (even if the systemic ventricle is a morphologic RV) and in patients with idiopathic dilated cardiomyopathy. Studies in children supporting the use of CRT include many case reports, a few studies of CRT in post-operative patients, and one multi-center registry reporting the use of CRT in children. These papers will be summarized.
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Batra et al. (2009) conducted a review in Heart failure and dilated cardiomyopathy in children and congenital heart disease. Cardiac Resynchronization Therapy was evaluated. Retrospective series suggest that cardiac resynchronization therapy is effective for managing dyssynchrony-associated heart failure in children and patients with congenital heart disease.
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