Key result
Low molecular weight heparin required no dose adjustment in 48% of patients compared to 24% with unfractionated heparin, with both groups achieving 50% phlebographic improvement.
Why the study?
Does low molecular weight heparin improve phlebographic outcomes or safety compared to unfractionated heparin in patients with deep venous thrombosis?
RCT (n=56)
Double-blind
Does low molecular weight heparin improve phlebographic outcomes or safety compared to unfractionated heparin in patients with deep venous thrombosis?
Absolute Event Rate: 50% vs 50%
Subcutaneous low molecular weight heparin appears as safe and effective as unfractionated heparin for the treatment of deep venous thrombosis, with less frequent need for dose adjustment.
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Supports LMWH as practical alternative to UFH in DVT; confirms comparable phlebographic efficacy with fewer dose adjustments.
Holm et al. (2009) conducted an RCT in Deep venous thrombosis (DVT) (n=56). Low molecular weight heparin (LH) vs. Unfractionated heparin (UH) was evaluated on Phlebographic improvement. Low molecular weight heparin required no dose adjustment in 48% of patients compared to 24% with unfractionated heparin, with both groups achieving 50% phlebographic improvement.
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