What question did this study set out to answer?

This research aims to identify factors in serum that enhance the conversion of prothrombin to thrombin.

June 1, 1949BloodOpen Access

A Factor in Serum Which Accelerates the Conversion of Prothrombin to Thrombin

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Why the study?

How do various physical and pharmacological factors affect the evolution of SPCA and residual prothrombin activity during blood coagulation?

Population

Normal subjects (blood samples)

Comparison

Mechanical agitation, addition of… vs Normal coagulation conditions

Design

Preclinical

Authors

BABenjamin AlexanderArkansas Children's Hospital AVAndré de VriesUniversity Medical Center Groningen RGRobert H. GoldsteinMassachusetts Department of Public Health

Discussion

Member takes

Implication

Physical and pharmacologic modulation of SPCA in animals is hypothesis-generating; leaves open translation to human coagulation management.

Key Points

This research aims to identify factors in serum that enhance the conversion of prothrombin to thrombin.
Studied serum samples from normal subjects
Examined effects of mechanical agitation and thromboplastin on prothrombin conversion
Investigated impact of heparin and siliconized apparatus on serum prothrombin levels
Mechanical agitation and thromboplastin increase SPCA and reduce prothrombin activity.
Heparin and siliconized handling decrease SPCA and increase residual prothrombin activity.
Dicumarol administration results in subnormal SPCA evolution during coagulation.

Structured PICO

How do various physical and pharmacological factors affect the evolution of SPCA and residual prothrombin activity during blood coagulation?

Population

Normal subjects (blood samples)

Intervention

Mechanical agitation, addition of thromboplastin, large doses of heparin, handling with siliconized apparatus, or dicumarol administration

Comparator

Normal coagulation conditions

Outcome

Evolution of serum prothrombin conversion accelerator (SPCA) and residual serum prothrombin activitysurrogate

This early study characterizes the factors influencing the evolution of serum prothrombin conversion accelerator (SPCA) during blood coagulation.

Cite This Study

Alexander et al. (1949) studied this question.

synapsesocial.com/papers/6a1c59f44ebd09f3dfa9bd38 https://doi.org/10.1182/blood.v4.6.739.739

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Implication

Physical and pharmacologic modulation of SPCA in animals is hypothesis-generating; leaves open translation to human coagulation management.

A Factor in Serum Which Accelerates the Conversion of Prothrombin to Thrombin

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

A Factor in Serum Which Accelerates the Conversion of Prothrombin to Thrombin

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider