What does this research mean for the field?

The human cerebral arterial tree complies with the principle of minimum work (Law of Murray) despite exhibiting large variations in branching parameters. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

October 17, 2018The Anatomical RecordOpen Access

Branching Pattern of the Cerebral Arterial Tree

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Normal cerebral arterial tree (n=5). Intervention: Measurement of cerebral arterial branching patterns. Primary outcome: Compliance with the principle of minimum work (Law of Murray) and branching pattern parameters.

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Key result

Human cerebral arterial tree adheres to the principle of minimum work despite notable regional branching variation.

Authors

JHJasper HelthuisIsala TDTristan P. C. van DoormaalUtrecht University BHBerend HillenRadboud University Nijmegen

Discussion

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Implication

Supports minimum-work compliance in cerebral arteries; leaves open standardization of branching metrics before research translation.

Study Design

Type

Observational (n=5)

PICO

Population

5 intact human brains without pathology from donors aged 50 to 89 years were analyzed to quantify the branching patterns of the cerebral arterial tree.

Exposure / Comparator

Measurement of cerebral arterial branching patterns

Primary Outcome

Compliance with the principle of minimum work (Law of Murray) and branching pattern parameters

Limitations

Samples of different subjects were used for different methods, making it unclear if differences are due to intersubject variability or technique.
Postmortem changes in vascular smooth muscle relaxation and contractility could impact measurements.
Tissue shrinkage due to fixation and storage methods.
Loss of axial stretch during dissection.
Potential systematic error from measuring compressed artery width and wall thickness.
Age of subjects might have affected morphology.
Differences in injection pressure during cast production.

Cite This Study

Helthuis et al. (2018) conducted an observational in Normal cerebral arterial tree (n=5). Measurement of cerebral arterial branching patterns was evaluated on Compliance with the principle of minimum work (Law of Murray) and branching pattern parameters. The human cerebral arterial tree complies with the principle of minimum work, though branching pattern parameters show large variation depending on measurement technique and vascular location.

synapsesocial.com/papers/6a1c5b9fea84844e355fc88d https://doi.org/10.1002/ar.23994

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Branching Pattern of the Cerebral Arterial Tree

Discussion

Member takes

Implication

Study Design

PICO

Limitations

Cite This Study

Branching Pattern of the Cerebral Arterial Tree

Discussion

Member takes

Implication

Study Design

PICO

Limitations

Cite This Study

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