Key result
Applied laminar shear stress induced a K+ ion current in cells expressing the endothelial Kir2.1 channel, a response that was specifically prevented by tyrosine kinase inhibition.
Why the study?
Does applied fluid shear stress induce a K(+) ion current in cells expressing the endothelial Kir2.1 channel?
Does applied fluid shear stress induce a K(+) ion current in cells expressing the endothelial Kir2.1 channel?
The study identifies the Kir2.1 channel as an early component of the endothelial shear response mechanism, which is regulated by tyrosine kinase.
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May implicate Kir2.1 in endothelial shear sensing; leaves open relevance to human vascular disease.
Hoger et al. (2002) studied Endothelial shear stress response. Laminar shear stress vs. No flow (stationary conditions) was evaluated on K+ shear current (IKS) amplitude. Applied laminar shear stress induced a K+ ion current in cells expressing the endothelial Kir2.1 channel, a response that was specifically prevented by tyrosine kinase inhibition.
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