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BACKGROUND: Systemic light chain (AL) amyloidosis is associated with a high mortality rate, particularly in the first year after diagnosis. Minimal residual disease (MRD) assessment plays a key role in the prognosis of AL amyloidosis but is typically performed later in the treatment process, thereby limiting its ability to guide early interventions. MATERIALS AND METHODS: flow cytometry after two chemotherapy cycles. The aim of this study was to assess the effect of early MRD negativity on organ response kinetics and prognosis. RESULTS: < 0.001). CONCLUSIONS: Early MRD negativity predicts faster/deeper organ responses in AL amyloidosis patients and is associated with improved prognosis. These findings offer new possibilities for integrating early MRD assessment into clinical practice.
Li et al. (Mon,) studied this question.